The New Testament contains two other words that are rendered as ignorance — agnoia and agnosia. The former is used to describe the sinful condition of the people when they went along with their leaders in the crucifixion of Jesus (Acts 3:17). Idolatry was a condition of spiritual ignorance that God winked at (Acts 17:30), overlooking it for a time.
This kind of ignorance is equated with blindness of heart (Eph. 4:18), and results in a darkened understanding and alienation from God. The end result of this kind of ignorance is invariably leads to being trapped in some kind of lust. Christians are to be obedient children and are to reject their former lusts, the lusts that were allowed by their spiritual ignorance (1 Pet. 1:14). In this case, ignorance makes room — ample room — for lust.
Ignorance also makes room for slander. With regard to agnosia, Christians are to live in a way that is submissive to the established civil authorities — and doing good in this way will shut up the spoken ignorance of foolish men (1 Pet. 2:15). Foolish men want to say that submission to Christ is a revolutionary threat to the civil order. It is a threat to the idolatries of the civil order, but not to the civil order per se. But this kind of ignorance has never been the master of nuance.
It is not just a problem outside the Church. This kind of culpable ignorance can take root within a Christian congregation. Paul tells the Corinthians to guard against this — “Awake to righteousness, and sin not; for some have not the knowledge of God: I speak this to your shame” (1 Cor. 15:34). There are many baptized members of churches, certified pew warmers, who are ignorant of God, and who need to be awakened to righteousness.